KMID : 0616120120430020107
|
|
Korean Journal of Pharmacognosy 2012 Volume.43 No. 2 p.107 ~ p.121
|
|
Terpenoids and Phenolics from Geum japonicum
|
|
Yean Min-Hye
Kim Ju-Sun Hyun Yu-Jae Hyun Jin-Won Bae Ki-Hwan Kang Sam-Sik
|
|
Abstract
|
|
|
Twenty-five compounds were isolated from the methanolic extract of Geum japonicum (Rosaceae), and their structures
were identified as eleven triterpenoids [ursolic acid 3-acetate (2), cecropiacic acid 3-methyl ester (3), pomolic acid 3-acetate (5), ursonic acid (6), ursolic acid (7), pomolic acid (8), corosolic acid (9), euscaphic acid (11), arjunic acid (16), tormentic acid (18), 23-hydroxytormentic acid (21)], two saponins [rosamultin (22) and kaji-ichigoside F1 (23)], two megastigmanes [blumenol A (14) and (+)-dehydrovomifoliol (15)], three flavonoids [apigenin (13), isoquercitrin (17) and tiliroside (24)], two ellagic acid derivatives [3,3¡¯-di-O-methylellagic acid (12) and ducheside B (25)] and five others [eugenol (1), emodin (4), vanillic acid (10), gallic aldehyde (19), salidroside (20)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. This is the first report of the eleven compounds, 2~6, 10, 15, 16, 20, 23, and 25 from the genus Geum, as well as the first report of apigenin (13) and 3,3¡¯-di-O-methylellagic acid (12) from G. japonicum. The antioxidant properties of 22 isolates (1~11, 14, 16~25) were evaluated by the intracellular reactive oxygen species (ROS) radical scavenging using 2¡¯,7¡¯ dichlorodihydrofluorescein diacetate (DCF-DA) assay. Among them, isoquercitrin (17) showed significant scavenging activity, and gallic aldehyde (19) and ducheside B (25) showed weak scavenging activity.
|
|
KEYWORD
|
|
Geum japonicum, Rosaceae, Isolation and identification, Terpenoids and phenolics, Antioxidant activity
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|